Protein dynamics · p53-family networks · Melanoma
Laboratory for Protein Dynamics
Ruđer Bošković InstituteWelcome to our lab
Mapping dynamic protein networks that shape tumour progression and treatment response
Principal investigator
Dr Neda Slade
Laboratory Head · Senior Research Adviser · Associate Professor
Research programmes
From isoform networks to environmental mutational signatures
p53 and p73 isoform networks in melanoma
We map how p53- and p73-family isoforms interact with NME and GLI proteins to shape melanoma progression, cell fate and therapeutic response.
Resistance to BRAF/MEK-targeted therapy
We investigate the protein and microRNA programmes that allow metastatic melanoma cells to acquire resistance to targeted treatment.
NME protein dynamics, migration and stress responses
We study NME1 and NME2 as dynamic regulators of cell migration, protein assembly and DNA-damage responses.
Aristolochic acid, mutational signatures and urothelial cancer
We use TP53 mutations and DNA adducts to define the carcinogenic imprint of aristolochic acid in endemic nephropathy-associated urinary-tract cancer.
Selected publications
Recent and defining work
The p53 Isoforms as Potential Biomarkers in Different Cancer Entities
International Journal of Molecular Sciences
p53 Family in Resistance to Targeted Therapy of Melanoma
International Journal of Molecular Sciences
Altered Expression of Shorter p53 Family Isoforms Can Impact Melanoma Aggressiveness
Cancers
p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies
Cancers
The Subcellular Localization and Oligomerization Preferences of NME1/NME2 upon Radiation-Induced DNA Damage
International Journal of Molecular Sciences
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